Case Western Reserve University School of Medicine researchers have made a groundbreaking discovery that could stop the proliferation of cancer cells in patients without the need for toxic chemotherapy.

The researchers discovered a mutant form of the gene Chk1. When expressed in cancer cells, it halted their proliferation and killed them. The finding that artificially activating Chk1 alone is enough to kill cancer cells is unprecedented.

"We have identified a new direction for cancer therapy... leading us to a reduction in toxicity in cancer therapy, compared with chemotherapy or radiation therapy," said Dr. Youwei Zhang, Assistant Professor with the Department of Pharmacology at the School of Medicine and a member of the Case Comprehensive Cancer Center, in a release. "With this discovery, scientists could stop the proliferation of cancer cells, allowing physicians time to fix cells and genetic errors."

If the researchers' strategy pans out, then cancer patients could potentially be treated by activating Chk1 in cancer cells, rather than using chemotherapy.

Future research by Dr. Zhang and his team will focus on approaches to artificially activating Chk1 in cancer cells.


Source: CWRU School of Medicine
Writer: Lee Chilcote

The communities competing for the $1 million Talent Dividend Prize have a modest goal: boosting the number of college degrees in their city by one percentage point. If every participating city meets that goal, it could raise national earnings by a stunning $124 billion.

In the best of cases, getting a book published can take one to three years from start to finish. Or, you can do it the way Richey Piiparinen and Anne Trubek did with Rust Belt Chic: The Cleveland Anthology. The pair of Cleveland writers managed to compress the entire Sisyphean process into an implausible three-month timeframe.

Thanks to the efforts of numerous neighborhood activists, once-blighted properties in Glenville and throughout Cleveland are being transformed into orchards, gardens and inviting green spaces. These incremental quality-of-life improvements are helping to craft a smaller city of higher quality.

The City of Cleveland and Cuyahoga County have invested millions of dollars in public money to help make urban development projects happen over the years. But do they provide the maximum benefit to the taxpayers paying for them?

Amanda Woodrum, a researcher at the liberal think tank Policy Matters, says that Northeast Ohio leaders have not always maximized the public benefits of development projects. Yet cities like Cleveland have a tool at their disposal called Community Benefit Agreements to help ensure the public gets the biggest bang for its buck when it comes to public subsidies.

"Community Benefit Agreements involve an economic development approach that balances the three E’s of sustainability: environment, equity and economy," says Woodrum. "One of the biggest things is ensuring that the workforce involved is hired locally. The second thing is that it is diverse and reflective of the population as a whole. There are other questions, too. Are we behaving responsibly towards the environment? Is there access to the development site for public transit?"

Woodrum adds, "The whole process is done in a very open discussion in which key stakeholders come together. There is a movement nationally to do development this way. In many cases, anchor institutions are voluntarilyy creating such agreements because they recognize that they have stake in community."

Woodrum stated that the City of Cleveland does not have a comprehensive policy towards creating Community Benefit Agreements with developers, and that the absence of such a policy can lead to inconsistent results. She cited the Horseshoe Casino as a potential model project due to its local hiring practices; on the other hand, a new housing development at Cleveland State University has drawn ire from the local building trades union for its failure to hire local workers.

To generate a discussion about Community Benefit Agreements in Cleveland, Policy Matters has helped to organize a daylong symposium with local and national experts at Cuyahoga Community College on Friday, August 3rd. The event is cosponsored by the City of Cleveland and Cleveland City Council.

"If the stakeholders coming to the table decide it makes sense, we’d like to move forward with building a policy that ensures whenever city subsidizes development in any meaninging way, we’re maximizing value to community," says Woodrum.


Source: Amanda Woodrum
Writer: Lee Chilcote

When late summer rolls around, my kids and I are desperate for adventure. From our house in the Heights, that usually means we’re heading down the hill to Cleveland, where over the years we’ve discovered countless family-friendly things to see and do. The options are many and growing, but here is our pick for Top 10.

One year ago, six interns from Dallas, Atlanta, Indianapolis, Boston, Baltimore and Jewett, Ohio came to Cleveland to participate in the inaugural year of Trinity Urban Service Corps, a project of Trinity Episcopal Cathedral in downtown Cleveland.

The goal of the program is to engage young people in nonprofit service work that improves the City of Cleveland. It also seeks to build community among members, stimulate faith development and help young people discern their career paths.

Adam Spencer, who organized the program for Trinity Cathedral, says it has been successful and is expanding to eight interns in its second year. A new crop of service corps members are scheduled to arrive in town next month.

"This program is all about working to make the city a better place," says Spencer, a Northeast Ohio native who loves playing the role of tour guide in his hometown. "The service corps members help to do the work we desperately need done in Cleveland. The program also gets young people interested in the city and its issues, and it shows them all the wonderful stuff that's going on here."

Trinity's service corps members live communally in a house in Detroit Shoreway. The program pays for their housing, transportation and health care and provides a modest stipend and shared allowance for groceries and utilities. Interns are encouraged to use public transportation as a way to navigate the city.

Some of the work sites included Detroit Shoreway Community Development Organization, West Creek Preservation Committee and Leadership Cleveland. Service corps members performed tasks ranging from community organizing to working with homeless men to organizing the Cleveland Mow Goats project.

The Trinity Urban Service Corps is part of a network of similar urban service corps that are organized by Episcopal congregations across the country.


Source: Adam Spencer
Writer: Lee Chilcote

More than 300 volunteers rolled up their shirtsleeves and got their hands dirty during the recent "Summer of Service" event hosted by Business Volunteers Unlimited on Thursday, July 18th. The event engaged young professionals in maintaining urban farms and gardens to support the regional food economy.

Some of the projects included constructing hoop houses and helping to maintain a .4 acre forest garden at Community Greenhouse Partners; working as an "urban farm hand for a day" in Detroit Shoreway by building garden beds and fencing; harvesting blueberries for the Cuyahoga Valley Farmers Market; and building a community garden at the Free Clinic. 

“Forty five of our interns volunteered at Schady Road Farm in Olmsted Township for the Cuyahoga County Board of Developmental Disabilities,” said Lisa Johnson, Corporate Responsibility Manager with Hyland Software, in a news release. “BVU’s ‘Done in a Day’ program is a great example of how our employees get out there and flex their muscles to help our community. They love it.”

“BVU works with employers year-round to engage their employees in meaningful volunteer service,” added Brian Broadbent, BVU’s president and CEO. “Our annual Summer of Service event is specifically targeted as an opportunity for employers to connect their interns and young professionals to community service.”

The tally at the end of a long day of volunteering was quite impressive: A collective 1,200 hours of service valued at more than $26,000, says BVU.


Source: Business Volunteers Unlimited
Writer: Lee Chilcote

“By 2015, more people will access the web from their smartphone than from their desktops and laptops,” says EXP president Barb Cagely. In Cleveland, numerous app developers are ahead of the curve, dreaming up mobile apps that do everything from enrich your tourism experience to making sure workers in the field have all the resources they need.

Louis Alloro isn't the first non native to touch down in Northeast Ohio and notice that Cleveland could use a collective mood lift, but he is pioneering a new effort to bring the science of happiness to Northeast Ohio.

The New York City native, who holds a Master's degree in Applied Positive Psychology from the University of Pennsylvania (he is one of the first 100 people in the world to hold this degree), discovered Cleveland's mild mood disorder when he visited his best friend here a few years ago. As soon as he set foot in the city, he had "a visceral sense that positive psychology would work really well here," he says.

After attending the Sustainable Cleveland conference in 2009, Alloro formed key partnerships with other Cleveland leaders interested in positive psychology. Soon afterwards, he relocated here and launched SOMO Cleveland, a project of SOMO Leadership Labs, which aims to "find and leverage the Social-Emotional (SOMO) Leaders around town, those who share a vision for a more positive future."

Recently, SoMo Cleveland hosted a screening of the documentary film "Happy." This film presents the argument that happiness stems not from one's material possessions, but from cultivating a sense of community, fostering experiences and personal connections, and giving back to other people. The film delves into the increasingly sophisticated science of happiness to show that income and material possessions account for only a modest amount of one's level of happiness.

The film also suggests that many Americans, who tend to privilege wealth above community building, relationship building and altruism as a means of creating happiness, are misguided. The science of happiness is directly applicable to Cleveland, Alloro says, because training people to seek happiness within themselves will lead to a stronger city focused on "positive self-growth."

Each month, SOMO Cleveland is hosting a series of free learning labs, book club discussions and film discussions, among other events, to engage Clevelanders.

"We want to give people experiences that help them build their own psychological muscle, then measure how they become more effective change agents," says Alloro. "We want to create an energy that promotes a viral sweep of well-being."


Source: Louis Alloro
Writer: Lee Chilcote

What if we viewed Cleveland as a startup? "The ingredients for a successful startup and a successful city are remarkably similar," argues tech blogger Jon Bischke. You need to build stuff that people want. You need to attract talent. And you need capital to get your fledgling ideas to a point of sustainability.